He was born on May 19, 1969 in Trabzon. He graduated from Karadeniz Technical University, Faculty of Engineering, Department of Mechanical Engineering. He completed his master's degree in Bahçeşehir University Urban Systems and Transportation Management program.

He started his career in Istanbul Metropolitan Municipality (IMM) Transportation Coordination Directorate in 1995. In 1998, he moved to the General Directorate of IETT. He worked as an engineer and manager in various units of IETT.

While working as the Deputy Director responsible for traffic control center, signalization and smart traffic systems at the IMM Traffic Directorate since 2002, he was appointed to the Transportation Coordination Directorate on 16 November 2009. He assumed the position of Head of Transportation Department on 23 July 2014.

Adil Karaismailoğlu was appointed as the Head of the Istanbul Real Estate Department at the Prime Ministry Mass Housing Administration (TOKİ) in July 2016, and as the Deputy Secretary General of the Istanbul Metropolitan Municipality in April 2018.

He has been serving as the Deputy Minister of Transport and Infrastructure since September 2019. He was appointed as Minister of Transport and Infrastructure on 27 March 2020.

Adil Karaismailoğlu is married and has two children.